Medvedev Dmitri G, Mausner Leonard F, Greene George A, Hanson Albert L
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA.
Appl Radiat Isot. 2008 Oct;66(10):1300-6. doi: 10.1016/j.apradiso.2008.02.090. Epub 2008 Mar 7.
The isotope (177)Lu is used in nuclear medicine and biology for in vivo applications as a radioactive label of various targeting agents. To extend the availability of no-carrier added (177)Lu, we investigated the feasibility of its production in a proton accelerator. Tantalum and Hf targets were irradiated and chemically processed to determine the radioisotope yield and cross-sections. The largest cross-sections (approximately 20 mb) were found for the Hf target at 195 MeV; however, the presence of co-produced Lu isotopes may limit the product applications. The results are in good agreement with theoretical data calculated using computer codes MCNPX and ORIGEN2S. Production of relevant medical isotopes such as (167)Tm and (169)Yb from the above targets is discussed as well.
同位素镥-177在核医学和生物学中用于体内应用，作为各种靶向剂的放射性标记物。为了扩大无载体添加镥-177的可得性，我们研究了在质子加速器中生产它的可行性。对钽靶和铪靶进行辐照并进行化学处理，以确定放射性同位素产率和截面。在195兆电子伏特下，铪靶的截面最大（约20毫靶）；然而，同时产生的镥同位素的存在可能会限制产品的应用。结果与使用计算机代码MCNPX和ORIGEN2S计算的理论数据高度一致。还讨论了从上述靶材生产相关医用同位素如铥-167和镱-169的情况。
