Radiochemistry Laboratory, Vernadsky Institute of Geochemistry and Analytical Chemistry of the Russian Academy of Sciences (GEOKHI RAS), Kosygin St., 19, 119991 Moscow, Russia.
Skobeltsyn Institute of Nuclear Physics, Lomonosov Moscow State University, Leninskie Gory, 1, Bld. 2, 119991 Moscow, Russia.
Molecules. 2022 May 16;27(10):3179. doi: 10.3390/molecules27103179.
A new method of production of one of the most widely used isotopes in nuclear medicine, Lu, with high chemical purity was developed; this method includes irradiation of the HfO target with bremsstrahlung photons. The irradiated target was dissolved in HF and then diluted and placed onto a column filled with LN resin. Quantitative sorption of Lu could be observed during this process. The column later was rinsed with the mixture of 0.1 M HF and 1 M HNO and then 2 M HNO to remove impurities. Quantitative desorption of Lu was achieved by using 6 M HNO. The developed method of Lu production ensures high purification of this isotope from macroquantities of hafnium and zirconium and radioactive impurities of carrier-free yttrium. The content of Lu in Lu in photonuclear production was determined. Due to high chemical and radionuclide purity, Lu obtained by the developed method can be used in nuclear medicine.
开发了一种新的生产核医学中应用最广泛的同位素之一镥（Lu）的方法，该方法具有高化学纯度；该方法包括用韧致辐射光子照射 HfO 靶。辐照后的靶溶解在 HF 中，然后稀释并放置在装满 LN 树脂的柱子上。在此过程中可以观察到 Lu 的定量吸附。然后用 0.1 M HF 和 1 M HNO 的混合物以及 2 M HNO 冲洗柱子以去除杂质。使用 6 M HNO 实现 Lu 的定量解吸。开发的 Lu 生产方法确保了从大量的铪和锆以及无载体放射性同位素钇中高度纯化该同位素。确定了光致生产中的 Lu 含量。由于具有高的化学和放射性核纯度，用所开发的方法获得的 Lu 可用于核医学。
