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用于通过氘核诱导天然镱的核反应以无载体添加形式生产用于代谢放射治疗的高比活度177g镥的激发函数。

Excitation function for deuteron induced nuclear reactions on natural ytterbium for production of high specific activity 177g Lu in no-carrier-added form for metabolic radiotherapy.

作者信息

Manenti Simone, Groppi Flavia, Gandini Andrea, Gini Luigi, Abbas Kamel, Holzwarth Uwe, Simonelli Federica, Bonardi Mauro

机构信息

LASA, Università degli Studi di Milano and INFN-Milano, via F.lli Cervi 201, I-20090 Segrate (MI), Italy.

出版信息

Appl Radiat Isot. 2011 Jan;69(1):37-45. doi: 10.1016/j.apradiso.2010.08.008. Epub 2010 Aug 13.

DOI:10.1016/j.apradiso.2010.08.008
PMID:20801665
Abstract

Deuteron-induced nuclear reactions for generation of no-carrier-added Lu radionuclides were investigated using the stacked-foil activation technique on natural Yb targets at energies up to E(d)=18.18 MeV. Excitation functions of the reactions (nat)Yb(d,xn)(169,170,171,172,173,174g,174m,176m,177g)Lu and (nat)Yb(d,pxn)(169,175,177)Yb have been measured, among them three ((169)Lu, (174m)Lu and (176m)Lu) are reported for the first time. The upper limit of the contamination from the long-lived metastable level (177m)Lu was evaluated too. Thick-target yields for all investigated radionuclides are calculated.

摘要

利用叠层箔活化技术，在能量高达E(d)=18.18 MeV的条件下，对天然镱靶进行了氘核诱发的核反应，以生成无载体添加的镥放射性核素。测量了反应(nat)Yb(d,xn)(169,170,171,172,173,174g,174m,176m,177g)Lu和(nat)Yb(d,pxn)(169,175,177)Yb的激发函数，其中三种((169)Lu、(174m)Lu和(176m)Lu)为首次报道。还评估了长寿命亚稳态(177m)Lu的污染上限。计算了所有研究放射性核素的厚靶产额。

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