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PAX3-FOXO1 fusion gene in rhabdomyosarcoma.
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PAX3-FOXO1 drives miR-486-5p and represses miR-221 contributing to pathogenesis of alveolar rhabdomyosarcoma.
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Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma.
Sci Transl Med. 2022 Jul 13;14(653):eabq2096. doi: 10.1126/scitranslmed.abq2096.
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Classification of rhabdomyosarcoma and its molecular basis.
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The PAX3-FOXO1 fusion protein present in rhabdomyosarcoma interferes with normal FOXO activity and the TGF-β pathway.
PLoS One. 2015 Mar 25;10(3):e0121474. doi: 10.1371/journal.pone.0121474. eCollection 2015.

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Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo.
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Fusion oncogenes in rhabdomyosarcoma: model systems, mechanisms of tumorigenesis, and therapeutic implications.
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Fusion genes in cancers: Biogenesis, functions, and therapeutic implications.
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Molecular Targets in Alveolar Rhabdomyosarcoma: A Narrative Review of Progress and Pitfalls.
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Tumors and their microenvironments: Learning from pediatric brain pathologies.
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Programmable protein stabilization with language model-derived peptide guides.
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Oncogenic gene fusions in cancer: from biology to therapy.
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Diagnosing and exploiting cancer's addiction to blocks in apoptosis.
Nat Rev Cancer. 2008 Feb;8(2):121-32. doi: 10.1038/nrc2297.
2
Effects of PAX3-FKHR on malignant phenotypes in alveolar rhabdomyosarcoma.
Biochem Biophys Res Commun. 2008 Jan 18;365(3):568-74. doi: 10.1016/j.bbrc.2007.11.017. Epub 2007 Nov 20.
3
PAX3-FOXO1 controls expression of the p57Kip2 cell-cycle regulator through degradation of EGR1.
Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18085-90. doi: 10.1073/pnas.0708910104. Epub 2007 Nov 6.
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The p53 family in differentiation and tumorigenesis.
Nat Rev Cancer. 2007 Mar;7(3):165-8. doi: 10.1038/nrc2072. Epub 2007 Feb 1.
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SP analysis may be used to identify cancer stem cell populations.
Exp Cell Res. 2006 Nov 15;312(19):3701-10. doi: 10.1016/j.yexcr.2006.08.030. Epub 2006 Sep 9.
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Validation of met as a therapeutic target in alveolar and embryonal rhabdomyosarcoma.
Cancer Res. 2006 May 1;66(9):4742-9. doi: 10.1158/0008-5472.CAN-05-4292.

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