Calvo Ana M
Department of Biological Sciences, Northern Illinois University, 1425 W. Lincoln Hwy Montgomery Hall, Dekalb, IL 60115, USA.
Fungal Genet Biol. 2008 Jul;45(7):1053-61. doi: 10.1016/j.fgb.2008.03.014. Epub 2008 Mar 31.
In fungi, the velvet gene, or veA, is involved in the regulation of diverse cellular processes, including control of asexual and sexual development as well as secondary metabolism. This global regulator is conserved in numerous fungal species. Interestingly, in Aspergilli, where most of the studies on veA have been carried out, this gene has been described to mediate development in response to light. In recent years the knowledge of this important regulatory system has expanded through the use of Aspergillus nidulans as a model organism, and through the study of veA orthologs across fungal genera. This review includes information on the current understanding of veA function and its mechanism of action. The fact that veA has only been found in fungi, together with advances in the elucidation of the veA mechanism, might be useful in designing future control strategies to decrease the detrimental effects of fungi while enhancing those qualities that are beneficial.
在真菌中，天鹅绒基因（即veA）参与多种细胞过程的调控，包括无性和有性发育的控制以及次级代谢。这种全局调节因子在众多真菌物种中是保守的。有趣的是，在曲霉属中，大多数关于veA的研究都是在该属中进行的，该基因已被描述为可响应光照介导发育。近年来，通过使用构巢曲霉作为模式生物，以及通过对真菌各属中veA直系同源物的研究，对这一重要调控系统的认识得到了扩展。本综述包括了关于目前对veA功能及其作用机制的理解的信息。veA仅在真菌中被发现这一事实，以及在veA机制阐明方面的进展，可能有助于设计未来的控制策略，以减少真菌的有害影响，同时增强其有益特性。
