VelB/VeA/LaeA复合物将光信号与真菌发育及次级代谢相协调。
VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism.
作者信息
Bayram Ozgür, Krappmann Sven, Ni Min, Bok Jin Woo, Helmstaedt Kerstin, Valerius Oliver, Braus-Stromeyer Susanna, Kwon Nak-Jung, Keller Nancy P, Yu Jae-Hyuk, Braus Gerhard H
机构信息
Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
出版信息
Science. 2008 Jun 13;320(5882):1504-6. doi: 10.1126/science.1155888.
Differentiation and secondary metabolism are correlated processes in fungi that respond to light. In Aspergillus nidulans, light inhibits sexual reproduction as well as secondary metabolism. We identified the heterotrimeric velvet complex VelB/VeA/LaeA connecting light-responding developmental regulation and control of secondary metabolism. VeA, which is primarily expressed in the dark, physically interacts with VelB, which is expressed during sexual development. VeA bridges VelB to the nuclear master regulator of secondary metabolism, LaeA. Deletion of either velB or veA results in defects in both sexual fruiting-body formation and the production of secondary metabolites.
分化和次级代谢是真菌中与光响应相关的过程。在构巢曲霉中，光会抑制有性生殖以及次级代谢。我们鉴定出了异源三聚体天鹅绒复合体VelB/VeA/LaeA，它连接了光响应的发育调控与次级代谢的控制。主要在黑暗中表达的VeA与在有性发育期间表达的VelB发生物理相互作用。VeA将VelB与次级代谢的核主调节因子LaeA连接起来。敲除velB或veA都会导致有性子实体形成和次级代谢产物产生方面的缺陷。
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