Barbier Mathieu, Delahaye Nicolas F, Fumoux Francis, Rihet Pascal
Aix-Marseille Université, IFR 48, Faculté de Pharmacie, Laboratoire de Pharmacogénétique des Maladies Parasitaires-EA 864, 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France.
Microbes Infect. 2008 May;10(6):673-9. doi: 10.1016/j.micinf.2008.03.001. Epub 2008 Mar 25.
Tumor necrosis factor (TNF)-related genes are thought to play a role in human malaria. TNF polymorphisms have been associated with severe malaria, mild malaria, and parasitemia. Lymphotoxin-alpha gene (LTA) that belongs to the TNF family is one such candidate gene. Here we report the family-based association analysis of a cis-regulatory lymphotoxin-alpha polymorphism with parasitemia in two independent populations living in Burkina Faso. Analysis of 199 subjects (34 families) living in an urban endemic area revealed the association of the low producing LTA+80A allele with reduced parasitemia. Furthermore, there was evidence of significant LTA+80-by-age and LTA+80-by-gender interactions. In another set of 318 residents (55 families) in a rural endemic area, we found both the association of the low producing LTA+80A allele with reduced parasitemia and LTA+80-by-age and LTA+80-by-gender interactions. This study suggests that LTA+80 polymorphism influences parasitemia and acts in an age- and gender-dependent manner.
肿瘤坏死因子（TNF）相关基因被认为在人类疟疾中发挥作用。TNF多态性与重症疟疾、轻症疟疾及寄生虫血症有关。属于TNF家族的淋巴毒素-α基因（LTA）就是这样一个候选基因。在此，我们报告了在布基纳法索生活的两个独立人群中，对一种顺式调控的淋巴毒素-α多态性与寄生虫血症进行的基于家系的关联分析。对生活在城市流行区的199名受试者（34个家庭）的分析显示，低产LTA +80A等位基因与寄生虫血症降低有关。此外，有证据表明LTA +80与年龄及LTA +80与性别之间存在显著相互作用。在农村流行区的另一组318名居民（55个家庭）中，我们发现低产LTA +80A等位基因与寄生虫血症降低有关，以及LTA +80与年龄及LTA +80与性别之间的相互作用。这项研究表明，LTA +80多态性影响寄生虫血症，并以年龄和性别依赖的方式起作用。
