Furuta Y, Shinohara T, Sano K, Nagashima K, Inoue K, Tanaka K, Inuyama Y
Department of Otolaryngology, Hokkaido University School of Medicine, Sapporo, Japan.
Laryngoscope. 1991 Jan;101(1 Pt 1):79-85. doi: 10.1288/00005537-199101000-00015.
Nasal inverted papilloma is a rare benign tumor occasionally associated with squamous cell carcinoma. To determine the etiological role of human papillomavirus in inverted papilloma, and to clarify the relationship between human papillomavirus and malignant transformation of this benign tumor, we retrospectively analyzed inverted papillomas from 26 patients, 7 of whom had squamous cell carcinoma. We used an immunohistochemical method and molecular pathologic techniques, or dot-blot hybridization of DNA extracted from paraffin-embedded tissues, in situ hybridization, and polymerase chain reaction. Human papillomavirus was detected in 5 of 26 patients (19%), 3 patients with human papillomavirus 11 and 2 patients with human papillomavirus 16. The latter 2 patients had inverted papillomas associated with squamous cell carcinoma. We speculate that human papillomavirus may be related to the malignant transformation of inverted papillomas.
鼻内翻性乳头状瘤是一种罕见的良性肿瘤，偶尔与鳞状细胞癌相关。为了确定人乳头瘤病毒在鼻内翻性乳头状瘤中的病因学作用，并阐明人乳头瘤病毒与这种良性肿瘤恶变之间的关系，我们回顾性分析了26例患者的鼻内翻性乳头状瘤，其中7例患有鳞状细胞癌。我们采用免疫组织化学方法和分子病理学技术，或对石蜡包埋组织提取的DNA进行斑点杂交、原位杂交及聚合酶链反应。26例患者中有5例（19%）检测到人乳头瘤病毒，3例为11型人乳头瘤病毒，2例为16型人乳头瘤病毒。后2例患者的鼻内翻性乳头状瘤与鳞状细胞癌相关。我们推测人乳头瘤病毒可能与鼻内翻性乳头状瘤的恶变有关。
