Alqudrah Fayssal, Kota Sharwani, Morgan Jason, Purnell Phillip R, McCormick Justin P
Department of Otolaryngology-Head and Neck Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
Otolaryngol Head Neck Surg. 2025 Apr;172(4):1155-1163. doi: 10.1002/ohn.1108. Epub 2024 Dec 31.
Prior studies have been contradictory on the role of human papillomavirus (HPV) infection in sinonasal inverted papilloma (SNIP) recurrence. This systematic review and meta-analysis was performed to further evaluate this potential association.
PubMed, Embase, and Scopus electronic databases.
Case-control studies reporting SNIP recurrence data and HPV status identified by polymerase chain reaction (PCR) and in-situ hybridization (ISH). Meta-analysis was performed to determine pooled odds ratios (ORs) and 95% confidence intervals (CI).
25 studies were identified including a total of 1116 benign SNIP tumors. A total of 267 SNIP were HPV+, 103 of which were recurrent, and 849 SNIP were HPV-, with 231 being recurrent. The pooled standard OR for recurrence in HPV+ tumors was 2.05 (95% CI: 1.31-3.19). Stratification by low-risk and high-risk HPV subtypes were not statistically significant. The standard OR for SNIP recurrence in low-risk and high-risk HPV+ subtypes were 1.57 (95% CI: 0.98-2.54) and 1.67 (95% CI: 0.98-2.80), respectively.
Infection with HPV may be associated with an increased risk of SNIP recurrence. This increased risk seems to be independent of HPV subtype based on low-risk or high-risk status. However, this correlation was variable among recently published studies requiring additional investigation.
先前的研究对于人乳头瘤病毒（HPV）感染在鼻窦内翻性乳头状瘤（SNIP）复发中的作用存在矛盾观点。进行这项系统评价和荟萃分析以进一步评估这种潜在关联。
PubMed、Embase和Scopus电子数据库。
病例对照研究报告了SNIP复发数据以及通过聚合酶链反应（PCR）和原位杂交（ISH）确定的HPV状态。进行荟萃分析以确定合并优势比（OR）和95%置信区间（CI）。
确定了25项研究，共包括1116例良性SNIP肿瘤。共有267例SNIP为HPV阳性，其中103例复发；849例SNIP为HPV阴性，231例复发。HPV阳性肿瘤复发的合并标准OR为2.05（95%CI：1.31 - 3.19）。按低风险和高风险HPV亚型分层无统计学意义。低风险和高风险HPV阳性亚型的SNIP复发标准OR分别为1.57（95%CI：0.98 - 2.54）和1.67（95%CI：0.98 - 2.80）。
HPV感染可能与SNIP复发风险增加相关。基于低风险或高风险状态，这种增加的风险似乎与HPV亚型无关。然而，这种相关性在最近发表的研究中存在差异，需要进一步研究。
