Zeyrek Fadile Yildiz, Babaoglu Aylin, Demirel Seda, Erdogan Derya Dirim, Ak Mucide, Korkmaz Metin, Coban Cevayir
Harran University Medical Faculty, Department of Microbiology, Sanliurfa, Turkey.
Am J Trop Med Hyg. 2008 May;78(5):729-32.
Plasmodium vivax is the second most prevalent global Plasmodium species causing malaria after P. falciparum. These two Plasmodium spp. co-exist in most endemic areas, apart from west and central Africa, which has only P. falciparum. However, southeastern Turkey is one of the exceptional regions with the sole presence of P. vivax infection, where a thorough epidemiologic survey has not been performed. Here, we report for the first time the identification of naturally acquired antibodies against the 19-kd C-terminal region of the merozoite surface protein-1 of P. vivax (PvMSP1(19)), using ELISA, from residents in the Sanliurfa region of southeastern Turkey. Among the 82 samples from patients with patent P. vivax malaria, 85% of the individuals were sero-reactive to PvMSP1(19). Particularly, 69.5% of the subjects were positive for IgM, 53.6% were positive for IgG (predominantly IgG1 and IgG3), and 7.3% were positive for IgA.
间日疟原虫是全球引起疟疾的第二大流行疟原虫物种，仅次于恶性疟原虫。除西非和中非仅存在恶性疟原虫外，这两种疟原虫在大多数流行地区共存。然而，土耳其东南部是仅存在间日疟原虫感染的特殊地区之一，尚未在此进行全面的流行病学调查。在此，我们首次报告，使用酶联免疫吸附测定法（ELISA），从土耳其东南部尚勒乌尔法地区的居民中鉴定出针对间日疟原虫裂殖子表面蛋白-1（PvMSP1）19-kd C端区域的自然获得性抗体。在82份间日疟现症患者样本中，85%的个体对PvMSP1（19）呈血清反应性。特别是，69.5%的受试者IgM呈阳性，53.6%的受试者IgG呈阳性（主要为IgG1和IgG3），7.3%的受试者IgA呈阳性。
