López Carolina, Yepes-Pérez Yoelis, Hincapié-Escobar Natalia, Díaz-Arévalo Diana, Patarroyo Manuel A
Molecular Biology and Immunology Department, Fundación Instituto de Immunología de Colombia (FIDIC), Bogotá, Colombia; PhD Programme in Biomedical and Biological Sciences, Universidad del Rosario, Bogotá, Colombia.
Molecular Biology and Immunology Department, Fundación Instituto de Immunología de Colombia (FIDIC), Bogotá, Colombia; MSc Programme in Microbiology, Universidad Nacional de Colombia, Bogotá, Colombia.
Front Immunol. 2017 Feb 13;8:126. doi: 10.3389/fimmu.2017.00126. eCollection 2017.
Malaria caused by continues being one of the most important infectious diseases around the world; is the second most prevalent species and has the greatest geographic distribution. Developing an effective antimalarial vaccine is considered a relevant control strategy in the search for means of preventing the disease. Studying parasite-expressed proteins, which are essential in host cell invasion, has led to identifying the regions recognized by individuals who are naturally exposed to infection. Furthermore, immunogenicity studies have revealed that such regions can trigger a robust immune response that can inhibit sporozoite (hepatic stage) or merozoite (erythrocyte stage) invasion of a host cell and induce protection. This review provides a synthesis of the most important studies to date concerning the antigenicity and immunogenicity of both synthetic peptide and recombinant protein candidates for a vaccine against malaria produced by .
由[具体疟原虫种类未给出]引起的疟疾仍然是全球最重要的传染病之一；[具体疟原虫种类未给出]是第二大流行种类，地理分布最广。开发一种有效的抗疟疫苗被认为是寻找预防该疾病方法的一项相关控制策略。对寄生虫表达的蛋白质进行研究，这些蛋白质在宿主细胞入侵中至关重要，这已导致确定了自然暴露于感染的个体所识别的区域。此外，免疫原性研究表明，这些区域可引发强大的免疫反应，该反应可抑制子孢子（肝期）或裂殖子（红细胞期）对宿主细胞的入侵并诱导保护作用。本综述综合了迄今为止关于由[具体疟原虫种类未给出]产生的抗疟疫苗的合成肽和重组蛋白候选物的抗原性和免疫原性的最重要研究。
