来自中国北京的患者和啮齿动物体内的汉坦病毒。（注：汉城病毒正式名称为汉坦病毒，此处根据语境推测原文想表达的是汉坦病毒相关内容）

Seoul virus in patients and rodents from Beijing, China.

作者信息

Zuo Shu-qing, Zhang Pan-he, Jiang Jia-fu, Zhan Lin, Wu Xiao-ming, Zhao Wen-juan, Wang Ri-min, Tang Fang, Dun Zhe, Cao Wu-chun

机构信息

Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China.

出版信息

Am J Trop Med Hyg. 2008 May;78(5):833-7.

PMID:18458321

Abstract

Hemorrhagic fever with renal syndrome (HFRS) is a significant public health problem with an increasing incidence in Beijing, China (report of disease surveillance from the Center for Disease Control and Prevention of Beijing, China). Hantaviruses were detected using RT-PCR method in blood samples of HFRS patients and lung tissues of rodents captured in Beijing. Phylogenetic analyses of 724bp partial S segment of the hantavirus gene showed that the detected Seoul virus (SEOV) fell into three different lineages, two of which circulated in Beijing. A nucleotide sequence identity of 99.7% for one of the cases of HFRS--the human- and Rattus norvegicus-originated SEOV sequences--had only two silent substitutions, suggesting genetic analysis is an essential tool for "case-investigation."

摘要

肾综合征出血热（HFRS）是一个重大的公共卫生问题，在中国北京其发病率呈上升趋势（来自中国北京市疾病预防控制中心的疾病监测报告）。采用逆转录聚合酶链反应（RT-PCR）方法，在北京的肾综合征出血热患者血液样本以及捕获的啮齿动物肺组织中检测到了汉坦病毒。对汉坦病毒基因724bp的部分S片段进行系统发育分析表明，检测到的汉城病毒（SEOV）分为三个不同的谱系，其中两个在北京传播。肾综合征出血热的一个病例（源自人和褐家鼠的汉城病毒序列）的核苷酸序列一致性为99.7%，仅有两个沉默替换，这表明基因分析是“病例调查”的重要工具。