Department of Epidemiology, School of Public Health, China Medical University, Shenyang, PR China.
BMC Infect Dis. 2011 Aug 26;11:229. doi: 10.1186/1471-2334-11-229.
Hemorrhagic fever with renal syndrome (HFRS) is a rodent-borne disease caused by Hantavirus, with characteristics of fever, hemorrhage, kidney damage, and hypotension. HFRS is recognized as a notifiable public health problem in China, and Liaoning Province is one of the most seriously affected areas with the most cases in China. It is necessary to investigate the spatial, temporal, and space-time distribution of confirmed cases of HFRS in Liaoning Province, China for future research into risk factors.
A cartogram map was constructed; spatial autocorrelation analysis and spatial, temporal, and space-time cluster analysis were conducted in Liaoning Province, China over the period 1988-2001.
When the number of permutation test was set to 999, Moran's I was 0.3854, and was significant at significance level of 0.001. Spatial cluster analysis identified one most likely cluster and four secondary likely clusters. Temporal cluster analysis identified 1998-2001 as the most likely cluster. Space-time cluster analysis identified one most likely cluster and two secondary likely clusters.
Spatial, temporal, and space-time scan statistics may be useful in supervising the occurrence of HFRS in Liaoning Province, China. The result of this study can not only assist health departments to develop a better prevention strategy but also potentially increase the public health intervention's effectiveness.
肾综合征出血热（HFRS）是一种由汉坦病毒引起的啮齿动物传播疾病，具有发热、出血、肾损伤和低血压的特征。HFRS 在中国被认为是一种需要报告的公共卫生问题，辽宁省是受影响最严重的地区之一，病例数在中国最多。有必要调查中国辽宁省 HFRS 确诊病例的空间、时间和时空分布，以便对危险因素进行未来研究。
构建了一幅变形地图；对中国辽宁省 1988-2001 年期间进行了空间自相关分析以及空间、时间和时空聚类分析。
当排列检验的数量设置为 999 时，Moran's I 为 0.3854，在 0.001 的显著性水平上显著。空间聚类分析确定了一个最可能的聚类和四个次要可能的聚类。时间聚类分析确定 1998-2001 年为最可能的聚类。时空聚类分析确定了一个最可能的聚类和两个次要可能的聚类。
时空扫描统计分析可能有助于监测中国辽宁省 HFRS 的发生。本研究的结果不仅可以帮助卫生部门制定更好的预防策略，还可以提高公共卫生干预的效果。
