Guo H, Wei J, Liu C S
Engineering Research Center of Biomedical Materials of Ministry of Education, Institute of Biomedical Materials, East China University of Science and Technology, Shanghai 200237, People's Republic of China.
Biomed Mater. 2006 Dec;1(4):193-7. doi: 10.1088/1748-6041/1/4/003. Epub 2006 Sep 13.
A new type of composite bone cement was prepared and investigated by adding calcium sulfate (CS) to calcium phosphate cement (CPC). This composite cement can be handled as a paste and easily shaped into any contour, which can set within 5-20 min, the setting time largely depending on the liquid-solid (L/S) ratio; adding CS to CPC had little effect on the setting time of the composite cements. No obvious temperature increase and pH change were observed during setting and immersion in simulated body fluid (SBF). The compressive strength of the cement decreased with an increase in the content of CS. The degradation rate of the composite cements increased with time when the CS content was more than 20 wt%. Calcium deficient apatite could form on the surface of the composite cement because the release of calcium into SBF from the dissolution of CS and the apatite of the cement induced the new apatite formation; increasing the content of CS in the composite could improve the bioactivity of the composite cements. The results suggested that composite cement has a reasonable setting time, excellent degradability and suitable mechanical strength and bioactivity, which shows promising prospects for development as a clinical cement.
通过向磷酸钙骨水泥（CPC）中添加硫酸钙（CS）制备并研究了一种新型复合骨水泥。这种复合水泥可作为糊剂处理，易于成型为任何形状，能在5 - 20分钟内凝固，凝固时间很大程度上取决于液固比（L/S）；向CPC中添加CS对复合水泥的凝固时间影响不大。在凝固过程以及浸泡于模拟体液（SBF）中时，未观察到明显的温度升高和pH变化。水泥的抗压强度随CS含量的增加而降低。当CS含量超过20 wt%时，复合水泥的降解速率随时间增加。由于CS溶解以及水泥中的磷灰石向SBF中释放钙从而诱导新的磷灰石形成，缺钙磷灰石可在复合水泥表面形成；增加复合材料中CS的含量可提高复合水泥的生物活性。结果表明，复合水泥具有合理的凝固时间、优异的降解性、合适的机械强度和生物活性，作为临床用水泥展现出良好的发展前景。
