Guo Han, Wei Jie, Yuan Yuan, Liu Changsheng
State Key Laboratory of Bioreactor Engineering, and Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, People's Republic of China.
Biomed Mater. 2007 Sep;2(3):S153-9. doi: 10.1088/1748-6041/2/3/S13. Epub 2007 Jul 30.
A new type of composite bone cement was prepared and investigated by adding calcium silicate (CS) to calcium phosphate cement (CPC). Low-crystalline CS prepared by heat treatment at low temperature had excellent bioactivity and degradability. Adding CS to CPC did not affect the phase composition and chemical structure of CPC, and had a little effect on the setting time and compressive strength of the composite cement. CS could effectively improve the in vitro and in vivo bioactivity of CPC, and enhance the cell proliferation on the CPC material. The introduction of CS is an effective way to improve the bioactivity and degradability of CPC, which will provide a new strategy to modify CPC.
通过向磷酸钙骨水泥（CPC）中添加硅酸钙（CS）制备并研究了一种新型复合骨水泥。低温热处理制备的低结晶CS具有优异的生物活性和可降解性。向CPC中添加CS不影响CPC的相组成和化学结构，对复合水泥的凝结时间和抗压强度影响较小。CS能有效提高CPC的体外和体内生物活性，并增强细胞在CPC材料上的增殖。CS的引入是提高CPC生物活性和可降解性的有效途径，将为改性CPC提供新策略。
