Sawan M, Laaziri Y, Mounaim F, Elzayat E, Corcos J, Elhilali M M
Polystim Neurotechnologies Laboratory-Ecole Polytechnique de Montréal, Department of Electrical Engineering, Montréal (QC), Canada.
Biomed Mater. 2007 Mar;2(1):S7-S15. doi: 10.1088/1748-6041/2/1/S02. Epub 2007 Mar 2.
The electrode-tissues interface (ETI) is one of the key issues in implantable devices such as stimulators and sensors. Once the stimulator is implanted, safety and reliability become more and more critical. In this case, modeling and monitoring of the ETI are required. We propose an empirical model for the ETI and a dedicated integrated circuit to measure its corresponding complex impedance. These measurements in the frequency range of 1 Hz to 100 kHz were achieved in acute dog experiments. The model demonstrates a closer fitting with experimental measurements. In addition, a custom monitoring device based on a stimuli current generator has been completed to evaluate the phase shift and voltage across the electrodes and to transmit wirelessly the values to an external controller. This integrated circuit has been fabricated in a CMOS 0.18 microm process, which consumes 4 mW only during measurements and occupies an area of 1 mm(2).
电极-组织界面（ETI）是诸如刺激器和传感器等可植入设备中的关键问题之一。一旦植入刺激器，安全性和可靠性就变得越来越重要。在这种情况下，需要对ETI进行建模和监测。我们提出了一种用于ETI的经验模型以及一个专用集成电路来测量其相应的复阻抗。在急性犬实验中实现了在1 Hz至100 kHz频率范围内的这些测量。该模型与实验测量结果拟合得更紧密。此外，基于刺激电流发生器的定制监测设备已完成，用于评估电极两端的相移和电压，并将这些值无线传输到外部控制器。该集成电路采用0.18微米CMOS工艺制造，仅在测量期间消耗4 mW功率，占用面积为1平方毫米。
