Huang Yong, Wang Yingjun, Ning Chengyun, Nan Kaihui, Han Yong
College of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, People's Republic of China.
Biomed Mater. 2007 Sep;2(3):196-201. doi: 10.1088/1748-6041/2/3/005. Epub 2007 Aug 23.
A porous hydroxyapatite (HA) coating on commercially pure titanium was prepared by micro-arc oxidation (MAO) in electrolytic solution containing calcium acetate and beta-glycerol phosphate disodium salt pentahydrate (beta-GP). The thickness, phase, composition morphology and biocompatibility of the oxide coating were characterized by x-ray diffraction (XRD), electron probe microanalysis (EPMA), scanning electron microscopy (SEM) with an energy dispersive x-ray spectrometer (EDS) and cell culture. The thickness of the MAO film was about 20 microm, and the coating was porous and uneven without any apparent interface to the titanium substrates. The result of XRD showed that the porous coating was made up of HA film. The favorable osteoblast cell affinity gives HA film good biocompatibility. HA coatings are expected to have significant uses for medical applications such as dental implants and artificial bone joints.
在含有醋酸钙和五水β-甘油磷酸二钠（β-GP）的电解液中，通过微弧氧化（MAO）在工业纯钛表面制备了多孔羟基磷灰石（HA）涂层。采用X射线衍射（XRD）、电子探针显微分析（EPMA）、配备能量色散X射线光谱仪（EDS）的扫描电子显微镜（SEM）以及细胞培养等方法对氧化涂层的厚度、相组成、形态和生物相容性进行了表征。微弧氧化膜的厚度约为20微米，涂层多孔且不均匀，与钛基体之间没有明显的界面。XRD结果表明，多孔涂层由HA膜组成。良好的成骨细胞亲和力赋予了HA膜良好的生物相容性。HA涂层有望在牙科植入物和人工骨关节等医学应用中具有重要用途。
