Ries T, Arndt C, Regier M, Graessner J, Cramer M C, Reitmeier F, Jaehne M, Adam G, Habermann C R
Department of Diagnostic and Interventional Radiology, Diagnostic Center, Hamburg, Germany.
Eur Radiol. 2008 Oct;18(10):2251-7. doi: 10.1007/s00330-008-0995-9. Epub 2008 May 6.
The purpose of the study was to investigate the value of diffusion-weighted (DW) echo-planar imaging (EPI) for quantifying physiological changes of the parotid gland before and after gustatory stimulation in patients suffering from acute or chronic recurrent inflammation in comparison with healthy volunteers. Using a DW-EPI sequence at 1.5 T, parotid glands of 19 consecutive patients with acute (n=14) and chronic (n=5) inflammation of parotid glands and 52 healthy volunteers were examined. Magnetic-resonance (MR) images were obtained before and after gustatory stimulation with 5 cc of lemon juice. In volunteers mean ADC values of 1.14 x 10(-3) mm(2)/s before and 1.2 x 10(-3) mm(2)/s after gustatory stimulation were observed. In acute inflammation ADC values were higher before [1.22 x 10(-3) mm(2)/s (p=0.006)] and after stimulation [1.32 x 10(-3) mm(2)/s (p<0.001)]. Before stimulation ADC differences between chronic inflammation (1.05 x 10(-3) mm(2)/s) and healthy volunteers (p=0.04) as well as between acute and chronic inflammation (p=0.005) were statistically significant. No differences were detected after stimulation between chronic inflammation (1.2 x 10(-3) mm(2)/s) and healthy volunteers (p=0.94) and between acute and chronic inflammation (p=0.15), respectively. DW-EPI seems to display the physiological changes of the parotid gland in patients suffering from acute or chronic inflammation and might be useful for discriminating healthy from affected glands.
本研究的目的是，与健康志愿者相比，探讨扩散加权（DW）回波平面成像（EPI）在量化患有急性或慢性复发性炎症患者味觉刺激前后腮腺生理变化方面的价值。使用1.5T的DW-EPI序列，对19例连续的腮腺急性（n = 14）和慢性（n = 5）炎症患者以及52名健康志愿者的腮腺进行了检查。在用5毫升柠檬汁进行味觉刺激前后获取磁共振（MR）图像。在志愿者中，味觉刺激前平均表观扩散系数（ADC）值为1.14×10⁻³mm²/s，刺激后为1.2×10⁻³mm²/s。在急性炎症中，刺激前ADC值较高[1.22×10⁻³mm²/s（p = 0.006）]，刺激后[1.32×10⁻³mm²/s（p < 0.001）]。刺激前，慢性炎症（1.05×10⁻³mm²/s）与健康志愿者之间（p = 0.04）以及急性与慢性炎症之间（p = 0.005）的ADC差异具有统计学意义。刺激后，慢性炎症（1.2×10⁻³mm²/s）与健康志愿者之间（p = 0.94）以及急性与慢性炎症之间（p = 0.15）均未检测到差异。DW-EPI似乎可以显示患有急性或慢性炎症患者腮腺的生理变化，并且可能有助于区分健康腮腺与患病腮腺。
