Chang Hing-Chiu, Juan Chun-Jung, Chiu Hui-Chu, Cheng Cheng-Chieh, Chiu Su-Chin, Liu Yi-Jui, Chung Hsiao-Wen, Hsu Hsian-He
Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan.
Eur Radiol. 2014 Sep;24(9):2069-76. doi: 10.1007/s00330-014-3265-z. Epub 2014 Jun 28.
To establish standard apparent diffusion coefficient (ADC) and the fat content as a function of age, gender and body mass index (BMI) in healthy parotid glands, and to address the influences of fat suppression on ADC measurements.
A total of 100 healthy adults (gender and age evenly distributed) were prospectively recruited, with parotid fat content measured from gradient-echo images with fat-water separated using iterative decomposition with echo asymmetry and least squares (IDEAL). The ADCs were estimated using both fat-saturated and non-fat-saturated diffusion-weighted imaging via a periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) technique.
Parotid fat content was larger in men than in women by about 10 percentage points (P < 0.005), and positively associated with BMI and age for both genders (mostly with P < 0.001). ADCs estimated with non-fat-saturated PROPELLER were significantly lower in men than in women (P < 0.005), but showed no gender difference if measured using fat-saturated PROPELLER (P = 0.840). The negative association between parotid ADC and age/BMI/fat (P < 0.001) showed greater regression slopes in non-fat-saturated PROPELLER than in fat-saturated data.
Parotid fat content in healthy adults correlates positively with both age and BMI; the correlation with age is gender-dependent. Parotid ADC measurements are strongly influenced by fat saturation.
Parotid fat content in healthy adults correlates positively with age and BMI. The rate of aging-related increase in fat contents is gender-dependent. Parotid ADC measurements are strongly influenced by fat saturation.
建立健康腮腺的标准表观扩散系数（ADC）以及脂肪含量与年龄、性别和体重指数（BMI）的函数关系，并探讨脂肪抑制对ADC测量的影响。
前瞻性招募了100名健康成年人（性别和年龄均匀分布），通过使用具有回波不对称和最小二乘法的迭代分解（IDEAL）进行脂肪-水分离的梯度回波图像测量腮腺脂肪含量。通过周期性旋转重叠平行线增强重建（PROPELLER）技术，使用脂肪饱和和非脂肪饱和扩散加权成像估计ADC。
男性腮腺脂肪含量比女性大约高10个百分点（P < 0.005），并且与BMI和年龄均呈正相关（大多P < 0.001）。使用非脂肪饱和PROPELLER估计的ADC在男性中显著低于女性（P < 0.005），但使用脂肪饱和PROPELLER测量时无性别差异（P = 0.840）。腮腺ADC与年龄/BMI/脂肪之间的负相关（P < 0.001）在非脂肪饱和PROPELLER数据中的回归斜率比脂肪饱和数据中的更大。
健康成年人的腮腺脂肪含量与年龄和BMI均呈正相关；与年龄的相关性存在性别差异。腮腺ADC测量受脂肪饱和的影响很大。
健康成年人的腮腺脂肪含量与年龄和BMI呈正相关。脂肪含量与年龄相关的增加速率存在性别差异。腮腺ADC测量受脂肪饱和的影响很大。
