Sadick Neil S
Weill Medical College of Cornell University, Department of Dermatology, New York, NY, USA.
J Drugs Dermatol. 2008 Apr;7(4):347-50.
The successful treatment of acne still remains problematic. Conventional therapies often prove inconsistent with unacceptable side effects and recurrence rates, leading to patient noncompliance. A thermal phototherapy treatment using a combination of blue light and red light has recently attracted much attention and seems to offer an effective alternative. The objective of this study was to evaluate the efficacy of blue light (415 nm) in combination with red light (633 nm) in the reduction of inflammatory lesions on the face of subjects (n=21) with mild to moderate acne vulgaris after a course of 8 20-minute (blue) or 30-minute (red) alternated light treatments, self-administered by a handheld unit over a period of 4 weeks. Lesion counts progressively reduced throughout the 4-week light therapy period and continued to reduce up to 8 weeks posttherapy, with a final average reduction of 69% seen 8 weeks after the treatment course (P>.001). This pattern is similar to previously reported studies.
痤疮的成功治疗仍然存在问题。传统疗法往往被证明效果不稳定,伴有不可接受的副作用和复发率,导致患者依从性差。一种结合蓝光和红光的热光疗法最近备受关注,似乎提供了一种有效的替代方法。本研究的目的是评估蓝光(415 nm)与红光(633 nm)联合使用对21名轻度至中度寻常痤疮患者面部炎症性皮损的疗效。治疗过程为使用手持设备进行为期4周的自我治疗,每周交替进行8次20分钟(蓝光)或30分钟(红光)的光照治疗。在为期4周的光疗期间,皮损数量逐渐减少,治疗后8周仍持续减少,治疗疗程结束8周后最终平均减少69%(P>0.001)。这种模式与先前报道的研究相似。