Goldberg David J, Russell Bruce A
Skin Laser & Surgery Specialists of New York/New Jersey, and Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10022, USA.
J Cosmet Laser Ther. 2006 Jun;8(2):71-5. doi: 10.1080/14764170600735912.
Acne vulgaris represents both a challenge to the treating dermatologist and a major concern for the patient. Conventional treatments have proved inconsistent with often unacceptable side effects and high rates of recurrence. Non-thermal, non-laser, phototherapy for acne with a combination of blue and red light has recently attracted attention. The present study was designed to assess the efficacy of this combination phototherapy.
Twenty-four subjects, Fitzpatrick skin types II-V, with mild to severe symmetric facial acne vulgaris were recruited for the study. Subjects were well matched at baseline in terms of both age and duration of acne. Subjects were treated over eight sessions, two per week 3 days apart, alternating between 415 nm blue light (20 minutes/session, 48 J/cm2) and 633 nm red light (20 minutes/session, 96 J/cm2) from a light-emitting diode (LED)-based therapy system. Patients received a mild microdermabrasion before each session. Acne was assessed at baseline and at weeks 2, 4, 8 and 12.
Twenty-two patients completed the trial. A mean reduction in lesion count was observed at all follow-up points. At the 4-week follow-up, the mean lesion count reduction was significant at 46% (p=0.001). At the 12-week follow-up, the mean lesion count reduction was also significant at 81% (p=0.001). Patient and dermatologist assessments were similar. Severe acne showed a marginally better response than mild acne. Side effects were minimal and transitory. Comedones did not respond as well as inflammatory lesions.
Combination blue and red LED therapy appears to have excellent potential in the treatment of mild to severe acne. Treatment appears to be both pain- and side effect-free.
寻常痤疮对皮肤科医生的治疗工作而言是一项挑战，也是患者主要关心的问题。传统治疗方法已被证明效果不一，副作用往往难以接受且复发率高。一种结合蓝光和红光的非热、非激光痤疮光疗法最近引起了关注。本研究旨在评估这种联合光疗法的疗效。
招募了24名Fitzpatrick皮肤分型为II - V型、患有轻至重度对称性面部寻常痤疮的受试者参与本研究。受试者在年龄和痤疮病程方面基线匹配良好。受试者接受8次治疗，每周2次，间隔3天，交替使用基于发光二极管（LED）的治疗系统发出的415nm蓝光（每次治疗20分钟，48J/cm²）和633nm红光（每次治疗20分钟，96J/cm²）。每次治疗前患者接受轻度微晶磨皮。在基线以及第2、4、8和12周对痤疮进行评估。
22名患者完成了试验。在所有随访点均观察到皮损数量平均减少。在4周随访时，皮损数量平均减少46%，差异有统计学意义（p = 0.001）。在12周随访时，皮损数量平均减少81%，差异也有统计学意义（p = 0.001）。患者和皮肤科医生的评估结果相似。重度痤疮的反应略优于轻度痤疮。副作用轻微且短暂。粉刺的反应不如炎性皮损。
联合蓝光和红光LED疗法在治疗轻至重度痤疮方面似乎具有巨大潜力。该治疗似乎无痛且无副作用。
