Highly sterically hindered olefins: a case of E- and Z-di-tert-butyl alpha,beta-unsaturated acids.
作者信息
Ionkin Alex S, Marshall William J, Fish Brian M
机构信息
DuPont Central Research & development, Experimental Station, Wilmington, Delaware 19880-0500, USA.
出版信息
Org Lett. 2008 Jun 5;10(11):2303-5. doi: 10.1021/ol800808g. Epub 2008 May 7.
PMID:18459796
Abstract
Use of a superbase in the Favorskii rearrangement of 12 resulted in the synthesis of highly sterically hindered olefins, (E)-2- tert-butyl-4,4-dimethyl-pent-2-enoic acid (4) and (Z)-2- tert-butyl-4,4-dimethyl-pent-2-enoic acid (3).
摘要
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