Mashburn-Warren L, McLean R J C, Whiteley M
Department of Molecular Genetics and Microbiology, The University of Texas at Austin, Austin, TX 78712, USA.
Geobiology. 2008 Jun;6(3):214-9. doi: 10.1111/j.1472-4669.2008.00157.x. Epub 2008 May 6.
Considerable interest has recently mounted regarding the biological roles of Gram-negative outer membrane vesicles (MVs). The first discovery of MVs was made over four decades ago, and it is now clear that most Gram-negative bacteria produce MVs, with Pseudomonas aeruginosa and Escherichia coli as the most extensively studied. Much of our knowledge of the biological roles of MVs and mechanism of MV formation is due to T.J. Beveridge and colleagues. Beveridge pioneered the field of MV research not only by enhancing our understanding of MV function, but also through the application of a wide variety of physical, chemical, and genetic techniques to complement his elegant electron microscopy investigations. Here we review the contributions of Beveridge's group to our understanding of MV biology.
近年来，革兰氏阴性菌外膜囊泡（MVs）的生物学作用引发了广泛关注。MVs的首次发现是在四十多年前，现在很清楚的是，大多数革兰氏阴性菌都会产生MVs，其中铜绿假单胞菌和大肠杆菌是研究最为广泛的。我们对MVs生物学作用和MVs形成机制的许多了解都归功于T.J. 贝弗里奇及其同事。贝弗里奇不仅通过增进我们对MV功能的理解，还通过应用各种各样的物理、化学和遗传学技术来补充他精湛的电子显微镜研究，开创了MV研究领域。在此，我们回顾贝弗里奇团队对我们理解MV生物学所做的贡献。
