以气胸、持续性漏气、急性呼吸窘迫综合征和多器官功能障碍为表现的快速进展性闭塞性细支气管炎并机化性肺炎：一例报告
Rapidly progressive Bronchiolitis Obliterans Organising Pneumonia presenting with pneumothorax, persistent air leak, acute respiratory distress syndrome and multi-organ dysfunction: a case report.
作者信息
Chakravorty Indranil, Oldfield William L G, Gómez Carlos M H
机构信息
Department of Respiratory Medicine, Lister Hospital, Beds & Herts Postgraduate Medical School, Stevenage, UK.
出版信息
J Med Case Rep. 2008 May 6;2:145. doi: 10.1186/1752-1947-2-145.
INTRODUCTION
Bronchiolitis Obliterans Organising Pneumonia (BOOP) may often present initially as a recurrent spontaneous pneumothorax and then develop multi-system complications.
CASE PRESENTATION
A 17-year-old boy presented with a pneumothorax, which developed into rapidly progressive Bronchiolitis Obliterans Organising Pneumonia (BOOP). He developed multi-organ dysfunction (including adult respiratory distress syndrome, oliguric renal failure, acute coronary syndrome, cardiac failure and a right atrial thrombus) which necessitated prolonged intensive care. Diagnosis was confirmed on open lung biopsy and he responded well to treatment with corticosteroids.
CONCLUSION
BOOP is exquisitely sensitive to oral corticosteroids but if the diagnosis is not considered in such patients and appropriate treatment instituted early, BOOP may often lead to prolonged hospital admission with considerable morbidity.
引言
闭塞性细支气管炎伴机化性肺炎（BOOP）最初常表现为复发性自发性气胸，随后发展为多系统并发症。
病例报告
一名17岁男孩出现气胸，进而发展为快速进展性闭塞性细支气管炎伴机化性肺炎（BOOP）。他出现了多器官功能障碍（包括成人呼吸窘迫综合征、少尿性肾衰竭、急性冠状动脉综合征、心力衰竭和右心房血栓形成），这需要长时间的重症监护。经开放性肺活检确诊，他对皮质类固醇治疗反应良好。
结论
BOOP对口服皮质类固醇极为敏感，但如果在此类患者中未考虑到该诊断且未早期进行适当治疗，BOOP往往会导致住院时间延长且伴有相当高的发病率。
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