皮下脂肪移植对新陈代谢的有益作用。
Beneficial effects of subcutaneous fat transplantation on metabolism.
作者信息
Tran Thien T, Yamamoto Yuji, Gesta Stephane, Kahn C Ronald
机构信息
Joslin Diabetes Center and Harvard Medical School, Boston, MA 02215, USA.
出版信息
Cell Metab. 2008 May;7(5):410-20. doi: 10.1016/j.cmet.2008.04.004.
Subcutaneous (SC) and visceral (VIS) obesity are associated with different risks of diabetes and the metabolic syndrome. To elucidate whether these differences are due to anatomic location or intrinsic differences in adipose depots, we characterized mice after transplantation of SC or VIS fat from donor mice into either SC or VIS regions of recipient mice. The group with SC fat transplanted into the VIS cavity exhibited decreased body weight, total fat mass, and glucose and insulin levels. These mice also exhibited improved insulin sensitivity during hyperinsulinemic-euglycemic clamps with increased whole-body glucose uptake, glucose uptake into endogenous fat, and insulin suppression of hepatic glucose production. These effects were observed to a lesser extent with SC fat transplanted to the SC area, whereas VIS fat transplanted to the VIS area was without effect. These data suggest that SC fat is intrinsically different from VIS fat and produces substances that can act systemically to improve glucose metabolism.
皮下（SC）肥胖和内脏（VIS）肥胖与糖尿病及代谢综合征的不同风险相关。为阐明这些差异是由于解剖位置还是脂肪储存部位的内在差异所致，我们对将供体小鼠的SC或VIS脂肪移植到受体小鼠的SC或VIS区域后的小鼠进行了特征分析。将SC脂肪移植到VIS腔的组体重、总脂肪量以及血糖和胰岛素水平均降低。这些小鼠在高胰岛素-正常血糖钳夹期间胰岛素敏感性也有所改善，全身葡萄糖摄取增加、内源性脂肪的葡萄糖摄取增加，且肝脏葡萄糖生成受到胰岛素抑制。将SC脂肪移植到SC区域时，这些效应程度较轻，而将VIS脂肪移植到VIS区域则无效果。这些数据表明，SC脂肪与VIS脂肪本质上不同，且能产生可在全身发挥作用以改善葡萄糖代谢的物质。
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