Kircher T
Universitätsklinik für Psychiatrie und Psychotherapie, RWTH Aachen, Germany.
Fortschr Neurol Psychiatr. 2008 May;76 Suppl 1:S24-32. doi: 10.1055/s-2008-1038124.
Alterations in thought and language are core symptoms of schizophrenia. Studies with structural and functional imaging (fMRI) as well as magneto/electroencephalography (EEG, MEG) on language in schizophrenia are reviewed which will help to reveal the correlates of formal thought disorder (FTD) and concretism. A model will be presented, where brain structure, function, receptorchemistry, cognitive deficits and psychopathology of language related phenomena are integrated. Positive formal thought disorder is correlated with a "functional" lesion in the superior temporal gyrus, part of Wernickes area. There is secondly a dysfunction of the semantic network, which is due to a language lateralisation deficit in the lateral temporal lobe in FTD. Further, a dysfunctional verbal self monitoring and error correction process in part responsible for FTD. Taken together, there is much evidence that the lateral temporal lobes bilaterally are predominantly involved in the generation of positive formal thought disorder in schizophrenia.
思维和语言的改变是精神分裂症的核心症状。本文综述了利用结构和功能成像（功能磁共振成像）以及磁/脑电图（脑电图、脑磁图）对精神分裂症语言进行的研究，这些研究将有助于揭示形式性思维障碍（FTD）和具体思维的相关因素。将提出一个模型，该模型整合了脑结构、功能、受体化学、认知缺陷以及语言相关现象的精神病理学。阳性形式性思维障碍与颞上回（韦尼克区的一部分）的“功能性”损伤相关。其次，语义网络存在功能障碍，这是由于FTD患者颞叶外侧语言偏侧化缺陷所致。此外，言语自我监测和错误纠正过程功能失调在一定程度上导致了FTD。综上所述，有充分证据表明双侧颞叶外侧在精神分裂症阳性形式性思维障碍的产生中起主要作用。
