Papazian D M, Timpe L C, Jan Y N, Jan L Y
Department of Physiology, University of California, San Francisco.
Nature. 1991 Jan 24;349(6307):305-10. doi: 10.1038/349305a0.
Voltage-dependent potassium, sodium and calcium ion channels may share a common mechanism of activation, in which the conserved S4 sequence acts as the primary voltage sensor. Site-directed mutagenesis of the S4 sequence of the Shaker potassium channel and electrophysiological analysis suggest that voltage-dependent activation involves the S4 sequence but is not solely due to electrostatic interactions.
电压依赖性钾离子、钠离子和钙离子通道可能共享一种共同的激活机制，其中保守的S4序列作为主要的电压感受器。对Shaker钾通道的S4序列进行定点诱变和电生理分析表明，电压依赖性激活涉及S4序列，但并非仅由静电相互作用引起。
