吸烟对沙特不育男性生殖激素和精液参数的影响。
Effect of smoking on reproductive hormones and semen parameters of infertile Saudi Arabians.
作者信息
Al-Turki Haifa A
机构信息
Department of Obstetrics and Gynecology, College of Medicine, University of Dammam, King Fahd Hospital of the University, Al Khobar, Saudi Arabia.
出版信息
Urol Ann. 2015 Jan-Mar;7(1):63-6. doi: 10.4103/0974-7796.148621.
OBJECTIVE
The purpose of this retrospective study is to look into the effect of smoking on semen and hormonal profile of Saudi Arabians attending infertility clinics.
MATERIALS AND METHODS
Medical record numbers of patients who attended infertility clinics and who underwent full assessment were identified rom Quadramed system and out-patient log books between January 2010 and December 2012. The standard protocol of the patients include full history, age, number of years of marriage personal habits of smoking, alcohol consumption, primary or secondary infertility. Standard laboratory tests which were performed, included, complete blood picture, random blood sugar, testosterone, follicle stimulation hormone, luteinizing hormone, prolactin level and semen analysis; volume, count, progressive motility and morphology. The data was entered in the database and analyzed.
RESULTS
During the study period, 279 patients attended and infertility clinic and only 258 gave the sample for analysis. The average age of patients in the smoking group was 34.23 ± 7.66 and in the nonsmokers 34.07 ± 7.92 years. Primary infertility was more common in smokers versus nonsmokers P < 0.001 confidence interval (CI)< -44.0705, total serum testosterone level was lower 383.8 ± 239.5 versus 422.5 ± 139.2 ng/dL (0.009 CI< -9.9415), serum prolactin level was higher 18.68 ± 13.28 versus 12.85 ± 12.34 ng/mL (0.001 CI < 8.3794). The average volume of the semen among the smokers was 2.8 ± 1.35 mL and in nonsmokers it was 3.08 ± 0.76 mL (P < 0.008 CI< -0.123). The mean progressive motility in smokers was 31.5 ± 23.1 compared to nonsmokers 40.05 ± 25.43% (0.002 CI< -3.2962) and total sperm count was 119.52 ± 114.12 and 139.71 ± 104.82 million/mL (0.07 CI < 1.4657).
CONCLUSIONS
This study shows that the effect of smoking is dramatic reduction in the hormonal levels and semen parameters. It is recommended that smoking men undergoing fertility treatment should stop smoking to increase their chances of having offspring.
目的
本回顾性研究旨在探究吸烟对前往不孕不育诊所就诊的沙特阿拉伯男性精液及激素水平的影响。
材料与方法
从Quadramed系统及门诊日志中确定2010年1月至2012年12月期间前往不孕不育诊所并接受全面评估的患者病历号。患者的标准诊疗流程包括完整病史、年龄、婚龄、吸烟及饮酒等个人习惯、原发性或继发性不孕情况。所进行的标准实验室检查包括血常规、随机血糖、睾酮、促卵泡激素、促黄体生成素、催乳素水平及精液分析；精液量、精子计数、前向运动率及形态。数据录入数据库并进行分析。
结果
研究期间，279名患者前往不孕不育诊所就诊，仅258名提供了分析样本。吸烟组患者的平均年龄为34.23±7.66岁，非吸烟组为34.07±7.92岁。与非吸烟者相比，原发性不孕在吸烟者中更为常见（P<0.001，置信区间（CI）<-44.0705），血清总睾酮水平较低，分别为383.8±239.5 ng/dL和422.5±139.2 ng/dL（0.009，CI<-9.9415），血清催乳素水平较高，分别为18.68±13.28 ng/mL和12.85±12.34 ng/mL（0.001，CI<8.3794）。吸烟者的平均精液量为2.8±1.35 mL，非吸烟者为3.08±0.76 mL（P<0.008，CI<-0.123）。吸烟者的平均前向运动率为31.5±23.1%，非吸烟者为40.05±25.43%（0.002，CI<-3.2962），精子总数分别为119.52±114.12百万/mL和139.71±104.82百万/mL（0.07，CI<1.4657）。
结论
本研究表明，吸烟会显著降低激素水平及精液参数。建议接受生育治疗的吸烟男性戒烟以增加生育后代的机会。
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