增殖性糖尿病视网膜病变患者的血浆和玻璃体同型半胱氨酸浓度
Plasma and vitreous homocysteine concentrations in patients with proliferative diabetic retinopathy.
作者信息
Aydemir Orhan, Türkçüoğlu Peykan, Güler Mete, Celiker Ulkü, Ustündağ Bilal, Yilmaz Turgut, Metin Kerem
机构信息
Department of Ophthalmology, Firat University School of Medicine, Elaziğ, Turkey.
出版信息
Retina. 2008 May;28(5):741-3. doi: 10.1097/IAE.0b013e31816079fb.
PURPOSE
An increase in plasma concentrations of homocysteine (Hcy) in proliferative diabetic retinopathy (PDR) has been described. The aim of this study was to investigate vitreous Hcy levels in patients with PDR.
METHODS
Plasma and vitreous samples were obtained simultaneously at the time of vitreoretinal surgery from 20 patients with PDR and 12 nondiabetic patients with nonproliferative ocular diseases. Hcy levels were determined by high-performance liquid chromatography.
RESULTS
The mean vitreous and plasma Hcy concentrations for the diabetic group were 3.64 +/- 0.65 micromol/L and 16.04 +/- 2.75 micromol/L, respectively. The mean intravitreal and plasma Hcy concentrations for the control group were 1.08 +/- 0.45 micromol/L and 9.18 +/- 3.91 micromol/L, respectively. Both plasma and vitreous Hcy concentrations for the diabetic group were significantly higher than those for the control group (P < 0.001). A statistically significant correlation between vitreous and plasma Hcy concentrations was present only for the diabetic group (r = 0.525; P = 0.017).
CONCLUSION
Vitreous Hcy concentrations were elevated in patients with PDR probably due to breakdown of the blood-retina barrier.
目的
已有研究报道增殖性糖尿病视网膜病变（PDR）患者血浆同型半胱氨酸（Hcy）浓度升高。本研究旨在调查PDR患者的玻璃体内Hcy水平。
方法
在玻璃体视网膜手术时，同时采集20例PDR患者和12例非糖尿病性非增殖性眼病患者的血浆和玻璃体样本。采用高效液相色谱法测定Hcy水平。
结果
糖尿病组玻璃体和血浆Hcy的平均浓度分别为3.64±0.65微摩尔/升和16.04±2.75微摩尔/升。对照组玻璃体内和血浆Hcy的平均浓度分别为1.08±0.45微摩尔/升和9.18±3.91微摩尔/升。糖尿病组的血浆和玻璃体Hcy浓度均显著高于对照组（P<0.001）。仅糖尿病组的玻璃体内和血浆Hcy浓度之间存在统计学上的显著相关性（r=0.525；P=0.017）。
结论
PDR患者的玻璃体内Hcy浓度升高，可能是由于血视网膜屏障破坏所致。
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