一种用于合成4(3H)-喹唑啉酮的微波辅助和杂多酸催化的环缩合反应。
A microwave-assisted and heteropolyacids-catalysed cyclocondensation reaction for the synthesis of 4(3H)-quinazolinones.
作者信息
Ighilahriz Karima, Boutemeur Baya, Chami Fariza, Rabia Cherifa, Hamdi Maâmar, Hamdi Safouane M
机构信息
Laboratoire de Chimie Organique Appliquée (Equipe Hétérocycles Associée CRAPC). Faculté de Chimie. Université des Sciences et de la Technologie Houari Boumediène. BP 32, El-Alia. 16111 Bab-Ezzouar. Alger, Algeria.
Laboratoire de Chimie du Gaz Naturel. Faculté de Chimie. Université des Sciences et de la Technologie Houari Boumediène. BP 32, El-Alia. 16111 Bab-Ezzouar. Alger, Algeria.
出版信息
Molecules. 2008 Apr 3;13(4):779-789. doi: 10.3390/molecules13040779.
We have investigated a microwave-assisted synthesis of 4(3H)-quinazolinones by condensation of anthranilic acid, orthoesters (or formic acid) and substituted anilines,using Keggin-type heteropolyacids (H(3)PW(12)O(40).13H(2)O, H(4)SiW(12)O(40).13H(2)O,H(4)SiMo(12)O(40).13H(2)O or H(3)PMo(12)O(40).13H(2)O) as catalysts. We found that the the use of H(3)PW(12)O(40).13H(2)O acid coupled to microwave irradiation allows a solvent-free, rapid (approximately 13min) and high-yielding reaction.
我们研究了以邻氨基苯甲酸、原酸酯（或甲酸）和取代苯胺为原料，通过缩合反应微波辅助合成4(3H)-喹唑啉酮的方法，使用Keggin型杂多酸（H(3)PW(12)O(40).13H(2)O、H(4)SiW(12)O(40).13H(2)O、H(4)SiMo(12)O(40).13H(2)O或H(3)PMo(12)O(40).13H(2)O）作为催化剂。我们发现，使用H(3)PW(12)O(40).13H(2)O酸并结合微波辐射可实现无溶剂、快速（约13分钟）且高产率的反应。
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