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微波增强硫酸化氧化锆和SZ/MCM-41在无溶剂条件下催化区域选择性合成β-氨基醇。

Microwave-enhanced sulphated zirconia and SZ/MCM-41 catalyzed regioselective synthesis of beta-amino alcohols under solvent-free conditions.

作者信息

Negrón-Silva Guillermo, Hernández-Reyes C Xochitl, Angeles-Beltrán Deyanira, Lomas-Romero Leticia, González-Zamora Eduardo

机构信息

Departamento de Ciencias Básicas, UAM, Av. San Pablo No 180, C.P. 02200, México DF, México.

出版信息

Molecules. 2008 Apr 26;13(4):977-85. doi: 10.3390/molecules13040977.

DOI:10.3390/molecules13040977
PMID:18463599
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6245303/
Abstract

A solvent-free approach for the regioselective synthesis of beta-amino alcohols in shorter reaction times and higher yields, compared to conventional heating is described. It involves microwave (MW) exposure of undiluted reactants in the presence of sulphated zirconia (SZ) or sulphated zirconia over MCM-41 (SZM) as catalyst. Both acid materials can be easily recovered and reused.

摘要

本文描述了一种无溶剂方法，与传统加热相比，该方法能在更短的反应时间内以更高的产率区域选择性合成β-氨基醇。该方法包括在硫酸化氧化锆（SZ）或负载于MCM-41上的硫酸化氧化锆（SZM）作为催化剂存在的情况下，对未稀释的反应物进行微波（MW）辐照。两种酸性材料都能很容易地回收和重复使用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33d4/6245303/43df4a681d98/molecules-13-00977-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33d4/6245303/98f5b7e3f4ff/molecules-13-00977-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33d4/6245303/4fe080990cdf/molecules-13-00977-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33d4/6245303/43df4a681d98/molecules-13-00977-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33d4/6245303/98f5b7e3f4ff/molecules-13-00977-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33d4/6245303/4fe080990cdf/molecules-13-00977-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33d4/6245303/43df4a681d98/molecules-13-00977-g002.jpg

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本文引用的文献

1
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2
Microwave-assisted ring opening of epoxides: a general route to the synthesis of 1-aminopropan-2-ols with anti malaria parasite activities.微波辅助环氧化物开环反应：合成具有抗疟原虫活性的1-氨基丙-2-醇的通用方法。
J Med Chem. 2007 Aug 23;50(17):4243-9. doi: 10.1021/jm070553l. Epub 2007 Aug 1.
3
Aqueous-phase aminolysis: approach for the analysis of epoxides in water.
Sulphated zirconia as an eco-friendly catalyst in acylal preparation under solvent-free conditions, acylal deprotection assisted by microwaves, and the synthesis of anhydro-dimers of o-hydroxybenzaldehydes.
硫酸锆作为一种环保型催化剂，用于无溶剂条件下的酰基化反应、微波辅助的酰基保护基脱除以及邻羟基苯甲醛的脱水二聚体合成。
Molecules. 2009 Oct 12;14(10):4065-78. doi: 10.3390/molecules14104065.
水相氨解：水中环氧化物的分析方法。
Anal Chem. 2006 Apr 15;78(8):2608-16. doi: 10.1021/ac0516990.
4
Highly chemoselective addition of amines to epoxides in water.胺类在水中对环氧化合物的高化学选择性加成反应。
Org Lett. 2005 Aug 18;7(17):3649-51. doi: 10.1021/ol051220q.
5
An efficient synthesis of 2-amino alcohols by silica gel catalysed opening of epoxide rings by amines.通过硅胶催化胺开环氧化合物环高效合成2-氨基醇。
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7
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