Aoi Takayuki
Department of Stem Cell Biology, Institute of Frontier Medical Sciences, Kyoto University.
Nihon Rinsho. 2008 May;66(5):850-6.
By retroviral transduction of four or three transcription factors, mouse and human somatic cells have been reprogrammed to an undifferentiated state similar to embryonic stem (ES) cells, and these cells have been termed induced pluripotent stem (iPS) cells. This technology has opened the avenue to generate patient- and disease-specific pluripotent stem cells, which are useful for not only customized cell transplantation therapy without rejection but also for understanding disease mechanisms, drug screening and toxicology. In this review, we discuss the overview of the advance of iPS cells.
通过逆转录病毒转导四个或三个转录因子，小鼠和人类体细胞已被重编程为类似于胚胎干细胞（ES细胞）的未分化状态，这些细胞被称为诱导多能干细胞（iPS细胞）。这项技术为生成患者和疾病特异性多能干细胞开辟了道路，这些干细胞不仅可用于无排斥反应的定制细胞移植治疗，还可用于了解疾病机制、药物筛选和毒理学。在本综述中，我们讨论了iPS细胞进展的概述。
