Vital A, Vital C, Ragnaud J M, Baquey A, Aubertin J
Department of Pathology, Hôpital Pellegrin, Bordeaux, France.
Virchows Arch A Pathol Anat Histopathol. 1991;418(1):83-5. doi: 10.1007/BF01600248.
In a patient with Waldenström's macroglobulinaemia and peripheral neuropathy, direct immunofluorescence of a peripheral nerve revealed the presence of abundant IgM and kappa light chain deposits in the endoneurium. Electron microscopic examination showed the microtubular structure of these endoneurial deposits, which strongly suggested the presence of cryoglobulin; this was then found in the serum.
在一名患有华氏巨球蛋白血症和周围神经病变的患者中，对其周围神经进行直接免疫荧光检查发现，神经内膜中有大量IgM和κ轻链沉积。电子显微镜检查显示这些神经内膜沉积物具有微管结构，强烈提示存在冷球蛋白；随后在血清中发现了冷球蛋白。
