与冷球蛋白血症相关的神经病变。
Neuropathy associated with cryoglobulinemia.
作者信息
Lippa C F, Chad D A, Smith T W, Kaplan M H, Hammer K
出版信息
Muscle Nerve. 1986 Sep;9(7):626-31. doi: 10.1002/mus.880090708.
PMID:3020402
Abstract
A patient with severe subacute sensory ataxia was found to have an IgM (kappa) cryoglobulin. Clinical, electrophysiologic, and sural nerve biopsy studies indicated that axonal degeneration and segmental demyelination both played a role in the pathogenesis of this neuropathy. Corticosteroid therapy was associated with notable clinical improvement and a 50% decrease in cryoglobulin concentration.
摘要
一名患有严重亚急性感觉性共济失调的患者被发现存在IgM（κ）冷球蛋白。临床、电生理和腓肠神经活检研究表明，轴索性变性和节段性脱髓鞘在这种神经病变的发病机制中均起作用。皮质类固醇治疗与显著的临床改善以及冷球蛋白浓度降低50%相关。
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