Clarençon F, Gutman F, Giannesini C, Pénicaud A, Galanaud D, Kerrou K, Marro B, Talbot J-N
Service de médecine nucléaire, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France.
J Neuroradiol. 2008 Oct;35(4):240-3. doi: 10.1016/j.neurad.2008.03.001. Epub 2008 May 7.
Creutzfeldt-Jakob disease (CJD) is a neurodegenerative disease caused by the accumulation of a pathogenic isoform of a prion protein in neurons that is responsible for subacute dementia. The Heidenhain variant is an atypical form of CJD in which visual signs are predominant. This is a report of the case of a 65-year-old man with probable CJD of the Heidenhain variant, with topographical concordance between findings on magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose (FDG) photopenic areas on positron emission tomography (PET)/computed tomography (CT) for cortical parietooccipital lesions.
克雅氏病（CJD）是一种神经退行性疾病，由朊病毒蛋白的致病性异构体在神经元中积累引起，可导致亚急性痴呆。海登海因变异型是CJD的一种非典型形式，以视觉症状为主。本文报告了一例65岁男性可能患有海登海因变异型CJD的病例，其磁共振成像（MRI）结果与正电子发射断层扫描（PET）/计算机断层扫描（CT）上皮质顶枕叶病变的18F-氟脱氧葡萄糖（FDG）低代谢区在位置上具有一致性。
