18F-氟脱氧葡萄糖-PET和99mTc-比西酯-SPECT在克雅氏病中的应用
18F-fluorodeoxyglucose-PET and 99mTc-bicisate-SPECT in Creutzfeldt-Jakob disease.
作者信息
Grünwald F, Pohl C, Bender H, Hartmann A, Menzel C, Ruhlmann J, Keller E, Biersack H J
机构信息
Department of Nuclear Medicine, University of Bonn, Germany.
出版信息
Ann Nucl Med. 1996 Feb;10(1):131-4. doi: 10.1007/BF03165066.
In a patient with the occipitoparietal form of Creutzfeldt-Jakob disease (CJD) (Heidenhain type) positron emission tomography (PET) demonstrated decreased glucose utilization in the occipital lobes and adjacent cortical regions. Single photon emission computed tomography (SPECT) with 99mTc-bicisate showed a "coupled" decrease in blood flow in identical cortical areas in this patient. In contrast, magnetic resonance imaging (MRI) was normal. In the early stage of CJD, when still no major morphological abnormalities can be observed, functional imaging is useful for differential diagnosis, particularly to exclude other causes of dementia or pathological EEG patterns.
在一名患有枕叶顶叶型克雅氏病（CJD）（海登海因型）的患者中，正电子发射断层扫描（PET）显示枕叶及相邻皮质区域的葡萄糖利用减少。该患者使用99mTc - 双半胱乙酯进行单光子发射计算机断层扫描（SPECT）显示相同皮质区域的血流呈“耦合”减少。相比之下，磁共振成像（MRI）结果正常。在CJD的早期，当仍未观察到明显的形态学异常时，功能成像有助于鉴别诊断，特别是用于排除痴呆或病理性脑电图模式的其他病因。
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