Guelfi K C, Tognim M C B, Cardoso C L, Gales A C, Carrara-Marrone F E, Garcia L B
Department of Clinical Analyses, Universidade Estadual de Maringá, Maringá, PR, Brazil.
J Chemother. 2008 Apr;20(2):180-5. doi: 10.1179/joc.2008.20.2.180.
The antimicrobial activity of meropenem combined with either polymyxin B or gatifloxacin was evaluated by the checkerboard method against Pseudomonas aeruginosa (10 strains) and Acinetobacter baumannii (10 strains). In addition, the triple combination of polymyxin B, gatifloxacin, and meropenem was also studied as well as the polymyxin B and gatifloxacin combination. A partial synergism interaction between meropenem and polymyxin B was observed for 80% of the A. baumannii strains. In contrast, this combination showed an indifferent effect for 80% of the P. aeruginosa strains tested. The combination of meropenem and gatifloxacin showed synergism only for two strains of A. baumannii, and partial synergism and additive effect for seven strains and indifference for four strains of both species. For the strains of P. aeruginosa, the double combination of polymyxin B and gatifloxacin and the triple combination of meropenem, polymyxin B and gatifloxacin were indifferent for the majority of the strains tested, that is, 90 and 80% respectively.
采用棋盘法评估美罗培南与多粘菌素B或加替沙星联合使用对铜绿假单胞菌（10株）和鲍曼不动杆菌（10株）的抗菌活性。此外，还研究了多粘菌素B、加替沙星和美罗培南的三联组合以及多粘菌素B与加替沙星的组合。在80%的鲍曼不动杆菌菌株中观察到美罗培南与多粘菌素B之间存在部分协同相互作用。相比之下，该组合对80%的受试铜绿假单胞菌菌株显示出无作用效果。美罗培南与加替沙星的组合仅对两株鲍曼不动杆菌显示出协同作用，对七株显示出部分协同作用和相加作用，对两种菌的四株显示出无作用效果。对于铜绿假单胞菌菌株，多粘菌素B与加替沙星的双联组合以及美罗培南、多粘菌素B与加替沙星的三联组合对大多数受试菌株无作用效果，分别为90%和80%。
