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类风湿关节炎中的高血压

Hypertension in rheumatoid arthritis.

作者信息

Panoulas V F, Metsios G S, Pace A V, John H, Treharne G J, Banks M J, Kitas G D

机构信息

Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Pensnett Road, Dudley, West Midlands DY1 2HQ, UK.

出版信息

Rheumatology (Oxford). 2008 Sep;47(9):1286-98. doi: 10.1093/rheumatology/ken159. Epub 2008 May 8.

Abstract

RA associates with an increased burden of cardiovascular disease, which is at least partially attributed to classical risk factors such as hypertension (HT) and dyslipidaemia. HT is highly prevalent, and seems to be under-diagnosed and under-treated among patients with RA. In this review, we discuss the mechanisms that may lead to increased blood pressure in such patients, paying particular attention to commonly used drugs for the treatment of RA. We also suggest screening strategies and management algorithms for HT, specific to the RA population, although it is clear that these need to be formally assessed in prospective randomized controlled trials designed specifically for the purpose, which, unfortunately, are currently lacking.

摘要

类风湿关节炎(RA)与心血管疾病负担增加相关,这至少部分归因于高血压(HT)和血脂异常等经典危险因素。HT非常普遍,在RA患者中似乎诊断不足且治疗不足。在本综述中,我们讨论了可能导致此类患者血压升高的机制,特别关注常用于治疗RA的药物。我们还针对RA人群提出了HT的筛查策略和管理算法,尽管很明显这些需要在专门为此目的设计的前瞻性随机对照试验中进行正式评估,遗憾的是目前还缺乏此类试验。

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