Wu Junru, Nyborg Wesley L
Department of Physics, Materials Science Program, University of Vermont, Burlington, VT 05405, USA.
Adv Drug Deliv Rev. 2008 Jun 30;60(10):1103-16. doi: 10.1016/j.addr.2008.03.009. Epub 2008 Apr 8.
This article reviews the basic physics of ultrasound generation, acoustic field, and both inertial and non-inertial acoustic cavitation in the context of localized gene and drug delivery as well as non-linear oscillation of an encapsulated microbubble and its associated microstreaming and radiation force generated by ultrasound. The ultrasound thermal and mechanical bioeffects and relevant safety issues for in vivo applications are also discussed.
本文回顾了超声产生的基本物理原理、声场，以及在局部基因和药物递送背景下的惯性和非惯性声空化，还有封装微泡的非线性振荡及其相关的微流和超声产生的辐射力。还讨论了超声热效应和机械生物效应以及体内应用的相关安全问题。
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