O'Neill Brian E, Li King C P
Department of Radiology, The Methodist Hospital, Houston, TX 77030, USA.
Int J Hyperthermia. 2008 Sep;24(6):506-20. doi: 10.1080/02656730802093661.
This paper reviews the enhanced delivery of genes, drugs and therapeutics using ultrasound. It begins with a general overview of the field and the various techniques associated with it, including sonophoresis, hyperthermia (with ultrasound), sonoporation, and microbubble assisted transvascular and targeted delivery. Particular attention is then paid to pulsed high intensity focused ultrasound drug delivery without the use of ultrasound contrast agents. Feasibility and mechanistic studies of this technique are described in some detail. Conclusions are then drawn regarding possible mechanisms of this treatment, and to contrast with the better known treatments relying on injection of ultrasound contrast agents.
本文综述了利用超声增强基因、药物和治疗剂的递送。文章首先对该领域以及与之相关的各种技术进行了总体概述，包括超声透皮给药、（超声辅助）热疗、声孔效应以及微泡辅助经血管靶向递送。接着特别关注了不使用超声造影剂的脉冲高强度聚焦超声药物递送。详细描述了该技术的可行性和机制研究。然后得出关于这种治疗可能机制的结论，并与更知名的依赖注射超声造影剂的治疗方法进行对比。
