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严重烧伤后出现的重度抑郁和创伤后应激障碍症状与终生精神疾病发病率的关系。

Major depression and posttraumatic stress disorder symptoms following severe burn injury in relation to lifetime psychiatric morbidity.

作者信息

Dyster-Aas Johan, Willebrand Mimmie, Wikehult Björn, Gerdin Bengt, Ekselius Lisa

机构信息

Departments of Neurosciences Psychiatry, University Hospital, Uppsala, Sweden.

出版信息

J Trauma. 2008 May;64(5):1349-56. doi: 10.1097/TA.0b013e318047e005.

Abstract

BACKGROUND

Psychiatric history has been suggested to have an impact on long-term adjustment in burn survivors. A rigorous, prospective, longitudinal approach was used to study psychiatric history in a population-based burn sample and its impact on symptomatology of depression and posttraumatic stress disorder (PTSD) at a 12-month follow-up.

METHODS

Seventy-three consecutive patients admitted to the Uppsala Burn Unit were assessed with the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition for psychiatric disorders, of whom 64 were also assessed after 12 months.

RESULTS

Forty-eight patients (66%) presented with at least one lifetime psychiatric diagnosis; major depression (41%), alcohol abuse or dependence (32%), simple phobia (16%), and panic disorder (16%) were most prevalent. At 12-months postburn, 10 patients (16%) met criteria for major depression, 6 (9%) for PTSD, and 11 (17%) for subsyndromal PTSD. Patients with lifetime anxiety disorder and with lifetime psychiatric comorbidity were more likely to be depressed at 12 months, whereas those with lifetime affective disorder, substance use disorder and psychiatric comorbidity were more likely to have symptoms of PTSD.

CONCLUSIONS

Two-thirds of burn survivors exhibit a history of lifetime psychiatric disorders. Those with a psychiatric history have a higher risk of postburn psychiatric problems.

摘要

背景

有研究表明精神病史会对烧伤幸存者的长期适应产生影响。本研究采用严格的前瞻性纵向研究方法,对一组基于人群的烧伤样本的精神病史及其在12个月随访时对抑郁症状和创伤后应激障碍(PTSD)的影响进行了研究。

方法

对乌普萨拉烧伤科连续收治的73例患者,采用《精神障碍诊断与统计手册》第四版的结构化临床访谈对精神疾病进行评估,其中64例患者在12个月后也接受了评估。

结果

48例患者(66%)至少有一项终生精神疾病诊断;最常见的是重度抑郁症(41%)、酒精滥用或依赖(32%)、单纯恐惧症(16%)和惊恐障碍(16%)。烧伤后12个月时,10例患者(16%)符合重度抑郁症标准,6例(9%)符合创伤后应激障碍标准,11例(17%)符合亚综合征创伤后应激障碍标准。有终生焦虑症和终生精神疾病共病的患者在12个月时更易出现抑郁,而有终生情感障碍、物质使用障碍和精神疾病共病的患者更易出现创伤后应激障碍症状。

结论

三分之二的烧伤幸存者有终生精神疾病史。有精神病史的患者烧伤后出现精神问题的风险更高。

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