Diers Martin, Koeppe Caroline, Yilmaz Pinar, Thieme Kati, Markela-Lerenc Jaana, Schiltenwolf Marcus, van Ackern Klaus, Flor Herta
Department of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
J Clin Neurophysiol. 2008 Jun;25(3):153-60. doi: 10.1097/WNP.0b013e31817759c5.
To determine the presence of perceptual sensitization and related brain responses we examined 15 patients with fibromyalgia syndrome and 15 healthy controls comparable in age and sex. Multichannel EEG recordings and pain ratings were obtained during the presentation of 800 painful electrical intramuscular and intracutaneous stimuli to the left m. erector spinae and the left m. extensor digitorum. The stimulus intensity was adjusted to 50% between pain threshold and tolerance. Detection and pain thresholds were significantly lower in the fibromyalgia syndrome group. Sensitization occurred for both groups during intramuscular stimulation. In the EEG data the fibromyalgia syndrome patients showed higher N80 amplitudes compared with the healthy controls. Arm stimulation and intramuscular stimulation yielded higher N80 and N150 amplitudes compared with intracutaneous stimulation or stimulation of the back. These results indicate lower pain thresholds in the fibromyalgia syndrome patients after electrical stimulation and a higher N80 amplitude both indicative of enhanced sensory processing in this group.
为了确定感知敏化及相关脑反应的存在情况，我们对15名纤维肌痛综合征患者和15名年龄及性别匹配的健康对照者进行了检查。在向左竖脊肌和左指伸肌施加800次疼痛性肌内和皮内电刺激的过程中，我们记录了多通道脑电图并进行了疼痛评分。刺激强度调整为介于疼痛阈值和耐受阈值之间的50%。纤维肌痛综合征组的检测阈值和疼痛阈值显著更低。两组在肌内刺激期间均出现了敏化现象。在脑电图数据中，与健康对照者相比，纤维肌痛综合征患者表现出更高的N80波幅。与皮内刺激或背部刺激相比，手臂刺激和肌内刺激产生了更高的N80和N150波幅。这些结果表明，电刺激后纤维肌痛综合征患者的疼痛阈值更低，且N80波幅更高，两者均表明该组的感觉处理增强。
