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肝细胞肿胀会增加肌醇1,4,5 -三磷酸、钙和环磷酸腺苷的浓度，但会拮抗Ca2(+)依赖性激素对磷酸化酶的激活作用。

Hepatocyte swelling increases inositol 1,4,5-trisphosphate, calcium and cyclic AMP concentration but antagonizes phosphorylase activation by Ca2(+)-dependent hormones.

作者信息

Baquet A, Meijer A J, Hue L

机构信息

Hormone and Metabolic Research Unit, University of Louvain Medical School, Brussels, Belgium.

出版信息

FEBS Lett. 1991 Jan 14;278(1):103-6. doi: 10.1016/0014-5793(91)80094-j.

DOI:10.1016/0014-5793(91)80094-j
PMID:1847108
Abstract

Swelling of hepatocytes increases the concentration of inositol 1,4,5-trisphosphate, Ca2+ and cAMP, without activating glycogen phosphorylase. In these hepatocytes, the activation of phosphorylase by suboptimal concentrations of vasopressin or angiotensin II was partly antagonized.

摘要

肝细胞肿胀会增加肌醇1,4,5 -三磷酸、钙离子和环磷酸腺苷的浓度，而不会激活糖原磷酸化酶。在这些肝细胞中，次优浓度的血管加压素或血管紧张素II对磷酸化酶的激活作用受到了部分拮抗。

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Hepatocyte swelling increases inositol 1,4,5-trisphosphate, calcium and cyclic AMP concentration but antagonizes phosphorylase activation by Ca2(+)-dependent hormones.肝细胞肿胀会增加肌醇1,4,5 -三磷酸、钙和环磷酸腺苷的浓度，但会拮抗Ca2(+)依赖性激素对磷酸化酶的激活作用。
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