Canfield Stephen M, Jacobson Judith S, Perzanowski Matthew S, Mellins Robert B, Zemble Robert M, Chew Ginger L, Goldstein Inge F
Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8 East, Suite 101, 622 West 168th St, New York, NY 10032, USA.
J Allergy Clin Immunol. 2008 Jun;121(6):1422-7, 1427.e1-4. doi: 10.1016/j.jaci.2008.03.011. Epub 2008 May 12.
Allergy and asthma risk share strong inherited components; however, the relative importance of maternal and paternal atopy in predicting child atopy remain unclear.
We sought to identify relationships between parents' and children's total and specific IgE levels within family units as predictors of allergic risk in children.
Total and allergen-specific IgE (to dust mite, cockroach, mouse, and cat) were determined by means of ImmunoCap (Phadia, Inc, Portage, Mich) in a sample of families participating in New York City Head Start programs. Regression models were developed to determine the associations of parents' and children's total IgE levels and sensitization patterns.
Blood specimens were collected from 161 family triads of mother, father, and child (83 boys and 78 girls). At a mean age of 4 years, boys had significantly higher total IgE levels than girls. Boys' total IgE levels were highly correlated with both mothers' (P < .002) and fathers' (P = .002) total IgE levels; girls' total IgE levels were not. Unlike total IgE levels, specific IgE levels among both boys and girls were associated with their mothers' specific IgE levels. Dust mite sensitization among mothers was predictive of children's sensitization to each of the 4 aeroallergens.
The strong associations between parents' and children's IgE levels suggest that assessment of parents' total and locally relevant allergen-specific IgE levels might have value in predicting atopy in children of preschool age.
过敏和哮喘风险具有很强的遗传因素；然而，母亲和父亲特应性在预测儿童特应性方面的相对重要性仍不明确。
我们试图确定家庭单位中父母与孩子的总IgE水平和特异性IgE水平之间的关系，以此作为儿童过敏风险的预测指标。
在参与纽约市“启智计划”项目的家庭样本中，采用免疫捕获法（Phadia公司，密歇根州波蒂奇）测定总IgE和过敏原特异性IgE（针对尘螨、蟑螂、小鼠和猫）。建立回归模型以确定父母与孩子的总IgE水平及致敏模式之间的关联。
收集了161个母亲、父亲和孩子组成的三联家庭的血标本（83名男孩和78名女孩）。平均年龄4岁时，男孩的总IgE水平显著高于女孩。男孩的总IgE水平与母亲（P < 0.002）和父亲（P = 0.002）的总IgE水平均高度相关；女孩的总IgE水平则不然。与总IgE水平不同，男孩和女孩的特异性IgE水平均与母亲的特异性IgE水平相关。母亲对尘螨致敏可预测孩子对4种空气过敏原中的每一种致敏。
父母与孩子IgE水平之间的强关联表明，评估父母的总IgE水平和局部相关过敏原特异性IgE水平可能对预测学龄前儿童的特应性有价值。
