Butts Thomas, Holland Peter W H, Ferrier David E K
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.
Trends Genet. 2008 Jun;24(6):259-62. doi: 10.1016/j.tig.2007.09.006. Epub 2008 May 9.
Comparison of whole genome sequences of representative animals enables reconstruction of the ancestral bilaterian genome: the starting point from which most extant animal lineages evolved. The Hox gene cluster patterns the anterior-posterior axis of bilaterians. Here we show that this cluster was embedded within a larger homeobox gene cluster, the Super-Hox cluster, in the ancestral bilaterian. This Super-Hox cluster contained at least eight genes alongside the core Hox genes ('EuHox' genes).
对代表性动物的全基因组序列进行比较，能够重建两侧对称动物的祖先基因组：这是大多数现存动物谱系进化的起点。Hox基因簇决定了两侧对称动物的前后轴模式。我们在此表明，在两侧对称动物的祖先中，这个基因簇嵌入在一个更大的同源异型框基因簇——超级Hox基因簇中。除了核心Hox基因（“真Hox”基因）外，这个超级Hox基因簇至少还包含八个基因。
