Rogers F B, Baumgartner N E, Robin A P, Barrett J A
Department of Surgery, University of Illinois College of Medicine Chicago.
J Trauma. 1991 Feb;31(2):200-4.
Polyglycolic acid mesh has been introduced as a method of controlling hemorrhage in severely damaged spleens. This study examines the effect of splenic wrapping on the immune function of the spleen, and also on its ability to control splenic bleeding in trauma patients. Thirty purebred beagle dogs were divided into three groups and subjected to sham operation (Group 1), splenectomy (Group 2), and splenic wrap (Group 3). Immunologic studies showed no difference between the wrapped group (Group 3) and those with their spleens intact (Group 1) in the induction of specific antibody-producing lymphocytes in splenic tissue after the injection of attenuated Pneumococci. All splenic injuries treated at Cook County Hospital between January 1985 and May 1988 were retrospectively analyzed. Of 60 patients with splenic injuries, 14 underwent mesh splenorrhaphy without mortality or serious complications. This study demonstrates that the immune function of spleen is preserved following mesh splenorrhapy, and that this technique can be used in a clinical setting with safe and efficacious results.
聚乙醇酸网已被引入作为控制严重受损脾脏出血的一种方法。本研究考察了脾脏包裹对脾脏免疫功能的影响，以及对创伤患者控制脾出血能力的影响。30只纯种比格犬被分为三组，分别接受假手术（第1组）、脾切除术（第2组）和脾脏包裹术（第3组）。免疫学研究表明，在注射减毒肺炎球菌后，包裹组（第3组）与脾脏完整组（第1组）在脾组织中诱导特异性抗体产生淋巴细胞方面没有差异。对1985年1月至1988年5月在库克县医院治疗的所有脾损伤进行了回顾性分析。在60例脾损伤患者中，14例接受了网片脾修补术，无死亡或严重并发症。本研究表明，网片脾修补术后脾脏免疫功能得以保留，且该技术可在临床应用中取得安全有效的结果。
