Gómez Rosso L, Meroño T, Benítez M B, López G, Giunta G, D'Ambrosio M L, Wikinski R, Cuniberti L, Brites F
Laboratory of Lipids and Lipoproteins, Department of Clinical Biochemistry, Institute of Physiopathology and Clinical Biochemistry, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, CONICET, Buenos Aires, Argentina.
Nutr Metab Cardiovasc Dis. 2009 Feb;19(2):135-9. doi: 10.1016/j.numecd.2008.02.008. Epub 2008 May 9.
Adiponectin is an adipokine highly and specifically expressed by adipose cells with antiatherogenic and antiinflammatory activities. The aim of the present study was to evaluate plasma adiponectin concentration in patients with primary hypertriglyceridemia and its relationship with metabolic parameters.
Male patients with primary hypertriglyceridemia and without the metabolic syndrome (n=22) were compared with normotriglyceridemic individuals (n=25). Plasma adiponectin concentration was measured by standardised enzyme-linked immunosorbent assay. Body mass index, waist circumference, glucose, insulin and non-esterified fatty acid levels, lipoprotein profile, and CETP activity were evaluated. Adiponectin levels were significantly decreased in hypertriglyceridemic patients in comparison with normotriglyceridemic subjects (4292+/-1717 vs. 6939+/-3249 ng/ml, p<0.005, respectively). Adiponectin was negatively associated with glucose (r=-0.44, p<0.01), insulin (r=-0.37, p<0.01), HOMA (r=-0.40, p<0.01), triglycerides (r=-0.36, p<0.01), VLDL-C (r=-0.34, p<0.05), and CETP (r=-0.47, p<0.001). Positive and significant correlations were observed with QUICKI (r=0.49, p<0.001) and HDL-C (r=0.33, p<0.05). In the multiple linear regression analysis, considering waist circumference, QUICKI, Log-triglycerides, HDL-C, and CETP as independent variables, Log-adiponectin showed a positive correlation with QUICKI, with an r(2)=0.229 and p<0.001. Therefore, the independent variable QUICKI explained the 23% of the variance in Log-adiponectin concentration.
We found low adiponectin levels in a population of primary hypertriglyceridemic men without the metabolic syndrome and an independent relationship between adiponectin concentration and insulin resistance. A reduction in insulin sensitivity and its impact on adiponectin concentration could be linked to high non-esterified fatty acid levels, increased triglyceride synthesis in the liver and impaired catabolism of triglyceride-rich lipoproteins.
脂联素是一种由脂肪细胞高度特异性表达的脂肪因子，具有抗动脉粥样硬化和抗炎活性。本研究旨在评估原发性高甘油三酯血症患者的血浆脂联素浓度及其与代谢参数的关系。
将原发性高甘油三酯血症且无代谢综合征的男性患者（n = 22）与甘油三酯正常的个体（n = 25）进行比较。采用标准化酶联免疫吸附测定法测量血浆脂联素浓度。评估体重指数、腰围、血糖、胰岛素和非酯化脂肪酸水平、脂蛋白谱以及胆固醇酯转运蛋白（CETP）活性。与甘油三酯正常的受试者相比，高甘油三酯血症患者的脂联素水平显著降低（分别为4292±1717 vs. 6939±3249 ng/ml，p<0.005）。脂联素与血糖（r = -0.44，p<0.01）、胰岛素（r = -0.37，p<0.01）、稳态模型评估胰岛素抵抗指数（HOMA）（r = -0.40，p<0.01）、甘油三酯（r = -0.36，p<0.01）、极低密度脂蛋白胆固醇（VLDL-C）（r = -0.34，p<0.05）和CETP（r = -0.47，p<0.
