Barr D G, Belton N R
Royal Hospital for Sick Children, Edinburgh.
Arch Dis Child. 1991 Jan;66(1):140-2. doi: 10.1136/adc.66.1.140.
The effects on mineral metabolism of therapeutic doses of corticosteroids were investigated in infantile cortical hyperostosis; in four untreated cases the calcium, phosphorus, and magnesium balances were strongly positive. In one severe case, treatment with prednisolone was associated with an alteration to negative calcium and magnesium balance, and faecal losses of calcium were particularly high. This effect persisted for at least three months after the steroids had been discontinued, and during this period there was pronounced retardation of linear growth. Six months after the treatment had been stopped mineral balance was again positive and there was rapid 'catch up' in growth. In infancy, the negative effect of corticosteroids on calcium, phosphorus, and magnesium metabolism may contribute to inhibition of bone growth and steroid stunting.
在婴儿皮质增生症中研究了治疗剂量的皮质类固醇对矿物质代谢的影响；在4例未经治疗的病例中，钙、磷和镁平衡呈强阳性。在1例重症病例中，泼尼松龙治疗导致钙和镁平衡变为负值，且粪便钙流失特别高。这种影响在停用类固醇后至少持续3个月，在此期间线性生长明显迟缓。治疗停止6个月后，矿物质平衡再次呈阳性，生长迅速“追赶”上来。在婴儿期，皮质类固醇对钙、磷和镁代谢的负面影响可能导致骨生长抑制和类固醇性发育迟缓。
