Uttley W S, Belton N R, Syme J, Sheppard H
Arch Dis Child. 1975 Mar;50(3):187-90. doi: 10.1136/adc.50.3.187.
Serial mineral balances have been obtained in 3 children undergoing therapy with EHDP (ethane-1-hydroxy-1, 1-diphosphonate) for diseases involving ectopic calcification. Although clinical outcome was not uniformly satisfactory, all cases showed an overall reduction in calcium balance. This was due to increased faecal excretion of calcium and was most marked after a long duration of therapy. Although these results conflict with reported experience in adults, they are in agreement with published observations of the effects of EHDP on calcium absorption in experimental animals.
对3名因异位钙化疾病接受依替膦酸二钠（EHDP）治疗的儿童进行了连续的矿物质平衡研究。尽管临床结果并非都令人满意，但所有病例的钙平衡总体上都有所下降。这是由于粪便中钙排泄增加所致，且在长期治疗后最为明显。尽管这些结果与报道的成人经验相矛盾，但与已发表的关于依替膦酸二钠对实验动物钙吸收影响的观察结果一致。
