Department of Pharmacology University Medical School Debrecen Debrecen H-4012 Hungary.
Mediators Inflamm. 1997;6(1):73-4. doi: 10.1080/09629359791974.
We have observed the symptoms of systemic inflammatory response syndrome (SIRS) in male rats intoxicated by carbon tetrachloride (CCl(4)). Severe hypothermia, tachypnoea and increase in the heart beat min were diagnosed. These symptoms developed in the first hour of intoxication. The hepatic dysfunction was characterized by elevated bilirubin levels. In the sera we have measured increases in the activity of secretable (group II) phospholipase A(2) sPLA(2) (2,8x) and 6-ketoprostaglandin F(1alpha) (KPGF) (1,44x). Supposedly the free radicals derived from CCl(4)-mainly trichloromethyl-could induce the prompt reaction of SIRS and the release of sPLA(2) as well as the formation of KPGF. Our findings show that in the early phase of CCl(4) intoxication the symptoms of SIRS can be related to elevation of sPLA(2) and the products of cyclooxygenase II.
我们观察到四氯化碳（CCl(4)）中毒雄性大鼠的全身炎症反应综合征（SIRS）症状。诊断出严重的低体温、呼吸急促和心跳加快。这些症状在中毒后的第一个小时内出现。肝功能障碍的特征是胆红素水平升高。在血清中，我们测量到分泌型（II 组）磷脂酶 A(2) sPLA(2)（2.8x）和 6-酮前列腺素 F(1alpha)（KPGF）（1.44x）的活性增加。据称，源自 CCl(4)的自由基——主要是三氯甲基——可能会引发 SIRS 的迅速反应以及 sPLA(2)的释放和 KPGF 的形成。我们的研究结果表明，在 CCl(4)中毒的早期阶段，SIRS 的症状可能与 sPLA(2)和环加氧酶 II 产物的升高有关。
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